cilengitide cil pre treatment Search Results


cilengitide trifluoroacetate  (MuseChem Chemicals)
N/A
Cilengitide (Cat No.:I004160) is a highly potent inhibitor of the αvβ3 and αvβ5 integrin receptors, with inhibitory concentration (IC50) values of 4.1 nM and 79 nM, respectively, in cell-free assays. It exhibits approximately 10-fold selectivity
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cilengitide tfa  (TargetMol)
N/A
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cilengitide cil  (MedChemExpress)
95
MedChemExpress cilengitide cil
Osteopontin (OPN) released by dendritic cells (DCs) modulates CCL5 production in DC/mesenchymal stromal cells (MSC) coculture. (A) DCs were cultured in the absence or in the presence of MSCs. Supernatants were harvested after 48 h and assayed by ELISA for CCL5 (left) and OPN (right) (mean ± SEM of four independent experiments). * p < 0.05 vs. DC alone by one-way ANOVA followed by Tukey’s Multiple Comparison Test. (B) MSC were incubated for 24 and 48 h with different concentrations of DC conditioned medium (DC-CM) and CCL5 concentrations were measured in the supernatants by ELISA (mean ± SEM of four independent experiments). * p < 0.05 vs. MSC alone at 24 and 48 h, respectively by Student’s t -test. (C) DCs and MSCs were cocultured for 48 h in the presence or in the absence of the antagonistic integrin inhibitors RGD (10 µg/ml) and <t>cilengitide</t> <t>(CIL)</t> (2 µg/ml). RGE was used as a control peptide. CCL5 concentrations were tested by ELISA. Results are expressed as % of CCL5 production by DC/MSC set as 100% and are representative of four independent experiments. * p < 0.05 vs. DC/MSC coculture in presence of RGE by Student’s t -test. (D) DCs were cultured alone or with MSCs (ratio DC/MSC 5:1) in the absence or in the presence of the proinflammatory cytokines (IL-1β, TNF-α, IL-6) for 48 h and OPN levels was determined in the supernatants by ELISA (mean ± SEM of seven different experiments). # p < 0.05 vs. DCs alone in the absence of cytokines; * p < 0.05 vs. MSCs alone in the presence of cytokines by Student’s t -test.
Cilengitide Cil, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cilengitide+cil+pre+treatment/Cilengitide/pmc05992779-61-31-33
Average 95 stars, based on 1 article reviews
cilengitide cil - by Bioz Stars, 2026-09
95/100 stars
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cil emd 121974  (Merck KGaA)
90
Merck KGaA cil emd 121974
Osteopontin (OPN) released by dendritic cells (DCs) modulates CCL5 production in DC/mesenchymal stromal cells (MSC) coculture. (A) DCs were cultured in the absence or in the presence of MSCs. Supernatants were harvested after 48 h and assayed by ELISA for CCL5 (left) and OPN (right) (mean ± SEM of four independent experiments). * p < 0.05 vs. DC alone by one-way ANOVA followed by Tukey’s Multiple Comparison Test. (B) MSC were incubated for 24 and 48 h with different concentrations of DC conditioned medium (DC-CM) and CCL5 concentrations were measured in the supernatants by ELISA (mean ± SEM of four independent experiments). * p < 0.05 vs. MSC alone at 24 and 48 h, respectively by Student’s t -test. (C) DCs and MSCs were cocultured for 48 h in the presence or in the absence of the antagonistic integrin inhibitors RGD (10 µg/ml) and <t>cilengitide</t> <t>(CIL)</t> (2 µg/ml). RGE was used as a control peptide. CCL5 concentrations were tested by ELISA. Results are expressed as % of CCL5 production by DC/MSC set as 100% and are representative of four independent experiments. * p < 0.05 vs. DC/MSC coculture in presence of RGE by Student’s t -test. (D) DCs were cultured alone or with MSCs (ratio DC/MSC 5:1) in the absence or in the presence of the proinflammatory cytokines (IL-1β, TNF-α, IL-6) for 48 h and OPN levels was determined in the supernatants by ELISA (mean ± SEM of seven different experiments). # p < 0.05 vs. DCs alone in the absence of cytokines; * p < 0.05 vs. MSCs alone in the presence of cytokines by Student’s t -test.
Cil Emd 121974, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cilengitide+cil+pre+treatment/synthetic+peptides+cilengitide/pmc04040659-111-0-7
Average 90 stars, based on 1 article reviews
cil emd 121974 - by Bioz Stars, 2026-09
90/100 stars
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cilengitide  (BOC Sciences)
N/A
Cilengitide is a cyclic Arg-Gly-Asp peptide with potential antineoplastic activity. Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. It is
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cilengitide  (Cayman Chemical)
N/A
CILENGITIDE
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cilengitide  (Biosynth Carbosynth)
N/A
Cilengitide is a cyclic arginine-glycine-aspartic acid (RGD) motif containing peptide that selectively inhibits the integrin alphav subunit. Integrins are cell adhesion molecules which mediate cell-cell and cell-matrix interactions and creating a scaffold for tissue organisation.
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cilengitide trifluoroacetate  (1PlusChem LLC)
N/A
Cilengitide trifluoroacetate
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cilengitide trifluoroacetate  (Biosynth Carbosynth)
N/A
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cilengitide trifluoroacetate  (Selleck Chemicals)
N/A
Cilengitide (EMD 121974, NSC 707544) is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.
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cilengitide tfa salt  (BOC Sciences)
N/A
Cilengitide TFA salt, is a cyclic Arg-Gly-Asp acid pentapeptide that induces anoikis in angiogenic blood vessels and brain tumor, selectively and potently blocks the ligation of theαvβ3 andαvβ5 integrins to provisional matrix proteins such as
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Image Search Results


Osteopontin (OPN) released by dendritic cells (DCs) modulates CCL5 production in DC/mesenchymal stromal cells (MSC) coculture. (A) DCs were cultured in the absence or in the presence of MSCs. Supernatants were harvested after 48 h and assayed by ELISA for CCL5 (left) and OPN (right) (mean ± SEM of four independent experiments). * p < 0.05 vs. DC alone by one-way ANOVA followed by Tukey’s Multiple Comparison Test. (B) MSC were incubated for 24 and 48 h with different concentrations of DC conditioned medium (DC-CM) and CCL5 concentrations were measured in the supernatants by ELISA (mean ± SEM of four independent experiments). * p < 0.05 vs. MSC alone at 24 and 48 h, respectively by Student’s t -test. (C) DCs and MSCs were cocultured for 48 h in the presence or in the absence of the antagonistic integrin inhibitors RGD (10 µg/ml) and cilengitide (CIL) (2 µg/ml). RGE was used as a control peptide. CCL5 concentrations were tested by ELISA. Results are expressed as % of CCL5 production by DC/MSC set as 100% and are representative of four independent experiments. * p < 0.05 vs. DC/MSC coculture in presence of RGE by Student’s t -test. (D) DCs were cultured alone or with MSCs (ratio DC/MSC 5:1) in the absence or in the presence of the proinflammatory cytokines (IL-1β, TNF-α, IL-6) for 48 h and OPN levels was determined in the supernatants by ELISA (mean ± SEM of seven different experiments). # p < 0.05 vs. DCs alone in the absence of cytokines; * p < 0.05 vs. MSCs alone in the presence of cytokines by Student’s t -test.

Journal: Frontiers in Immunology

Article Title: Adaptive Regulation of Osteopontin Production by Dendritic Cells Through the Bidirectional Interaction With Mesenchymal Stromal Cells

doi: 10.3389/fimmu.2018.01207

Figure Lengend Snippet: Osteopontin (OPN) released by dendritic cells (DCs) modulates CCL5 production in DC/mesenchymal stromal cells (MSC) coculture. (A) DCs were cultured in the absence or in the presence of MSCs. Supernatants were harvested after 48 h and assayed by ELISA for CCL5 (left) and OPN (right) (mean ± SEM of four independent experiments). * p < 0.05 vs. DC alone by one-way ANOVA followed by Tukey’s Multiple Comparison Test. (B) MSC were incubated for 24 and 48 h with different concentrations of DC conditioned medium (DC-CM) and CCL5 concentrations were measured in the supernatants by ELISA (mean ± SEM of four independent experiments). * p < 0.05 vs. MSC alone at 24 and 48 h, respectively by Student’s t -test. (C) DCs and MSCs were cocultured for 48 h in the presence or in the absence of the antagonistic integrin inhibitors RGD (10 µg/ml) and cilengitide (CIL) (2 µg/ml). RGE was used as a control peptide. CCL5 concentrations were tested by ELISA. Results are expressed as % of CCL5 production by DC/MSC set as 100% and are representative of four independent experiments. * p < 0.05 vs. DC/MSC coculture in presence of RGE by Student’s t -test. (D) DCs were cultured alone or with MSCs (ratio DC/MSC 5:1) in the absence or in the presence of the proinflammatory cytokines (IL-1β, TNF-α, IL-6) for 48 h and OPN levels was determined in the supernatants by ELISA (mean ± SEM of seven different experiments). # p < 0.05 vs. DCs alone in the absence of cytokines; * p < 0.05 vs. MSCs alone in the presence of cytokines by Student’s t -test.

Article Snippet: Supernatants were collected after 24 or 48 h. Where specified, DCs, MSCs, or the direct coculture of DC/MSC were treated for 48 h with 10 μg/ml Arg-Gly-Asp (RGD) (Sigma-Aldrich), 2 μg/ml cilengitide (CIL) (MedChem Express, NJ, USA), or the scrambled peptide Arg-Gly-Glu (RGE) (Sigma-Aldrich).

Techniques: Cell Culture, Enzyme-linked Immunosorbent Assay, Comparison, Incubation, Control